Research enabled by the Zuckerman Institute’s Cellular Imaging Platform
Top-Down Control of Sweet and Bitter Taste in the Mammalian Brain
Hao Jin, Hershel Fishman, Mingyu Ye, Li Wang and Charles S. Zuker. (2021) Cell
Highlights
Sweet and bitter are represented in the brainstem by genetically distinct neurons
SST+ and CALB2+ neurons in the brainstem carry bitter and sweet signals to the cortex
Feedback from bitter cortex amplifies bitter but suppresses incoming sweet taste signals
Cortical feedback via amygdala ensures bitter-evoked behavioral aversion remains robust
This project used the UltraMicroscopeII Light Sheet Microscope for imaging brain cleared using the CUBIC protocol.