Top-Down Control of Sweet and Bitter Taste in the Mammalian Brain

UltraMicroscopeII
Written By Luke Hammond
 
analysis header.PNG
 

Hao Jin, Hershel Fishman, Mingyu Ye, Li Wang and Charles S. Zuker. (2021) Cell

Highlights

  • Sweet and bitter are represented in the brainstem by genetically distinct neurons

  • SST+ and CALB2+ neurons in the brainstem carry bitter and sweet signals to the cortex

  • Feedback from bitter cortex amplifies bitter but suppresses incoming sweet taste signals

  • Cortical feedback via amygdala ensures bitter-evoked behavioral aversion remains robust

This project used the UltraMicroscopeII Light Sheet Microscope for imaging brain cleared using the CUBIC protocol.

Luke Hammond https://cellularimaging.org
Previous

Integrins protect sensory neurons in models of paclitaxel-induced peripheral sensory neuropathy